Authors:

Jayla N Wilcox

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About Paper:

Environmental factors, such as metals, significantly impact the exposome, potentially heightening susceptibility to cognitive impairment and Alzheimer's disease and related dementias. This study aims to quantify heavy metals, including lead, cadmium, mercury, arsenic, among others, in dried blood spots (DBS) obtained from participants in the Health and Retirement Survey (HRS). Utilizing energy-dispersive X-ray fluorescence (EDXRF) and advanced analytical techniques, the research aims to characterize and elucidate patterns of metal mixtures present. The DBS samples collected from HRS participants, aged 51 and older, have been preserved for retrospective analysis of body metal levels spanning a 14-year period. To support this investigation, EDXRF was employed for the assessment of heavy metal concentrations in dried blood spots. Although traditionally used for analyzing metals in air filters, recent technological advancements have significantly boosted the sensitivity of EDXRF, enabling precise measurement of lead, cadmium, mercury, and arsenic among the 15,000 participants included in the HRS study cohort. This comprehensive approach facilitates a detailed exploration of metal exposure patterns and their potential implications for health outcomes in older adults. Keywords: X-Ray; Blood Spot

Source:

Purdue University / 2024

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No topics listed

Co-authors:

Jayla N Wilcox