Authors:

John Ward Robbins

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About Paper:

In the Jaiswal laboratory, our research focuses on understanding how metabolic signaling pathways, specifically the AKT pathway, influence the plasticity of skeletal muscle and neuromuscular junctions (NMJs). We investigate how alterations in AKT signaling contribute to changes in skeletal muscle mass, function, and adaptive responses, particularly in conditions such as obesity and sarcopenia. Using genetic mouse models and human subjects, our study aims to unravel the molecular mechanisms underlying these physiological changes. The outcomes of our research are crucial for developing targeted therapies aimed at preserving muscle health and function in populations affected by metabolic disorders and age-related muscle degeneration. By gaining deeper insights into AKT-mediated metabolic signaling, we aim to identify potential therapeutic targets that could enhance muscle integrity and mobility, thereby improving the overall quality of life for aging individuals and those with metabolic disorders. Keywords: Metabolic Signaling; AKT Pathway; Neuromuscular Junctions (NMJs); Age-Related Muscle Degeneration; Muscle Mass

Source:

Purdue University / 2024

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Co-authors:

John Ward Robbins