Authors:

Katy Brauer

Date Created:

Not specified

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About Paper:

Flash Nanoprecipitation (FNP) is a scalable nanoparticle preparation technique that utilizes the amphiphilic nature of stabilizing polymers to encapsulate a particle core composed of a hydrophobic substance. FNP has a range of applications across various fields including agriculture, electronics, and pharmaceuticals. Using FNP in the formulation of nanoparticle delivery vehicles for hydrophobic therapeutics has resulted in improved bioavailability when compared to traditional crystalline dosages due to the amorphous character of the particle core and the high specific surface area of the particle itself. The turbulent flow from miscible solvent and antisolvent streams produces an instantaneous homogeneous mixing environment in which particle formation occurs at a rate much faster than nanoparticle self-assembly (1.5-5ms compared to 20-100ms). These conditions make particle production precise and reproducible, and high flow rates provide an ease of scalability that other preparation methods lack. Current processes employ a secondary antisolvent dilution step after particles have been formed to prevent the dissolution of stabilizing polymers from the particle core, and some also include an additional filtration procedure to increase solute concentration. The solution is then sent to a spray dryer, which uses heated gas flow to evaporate the liquid phase, leaving the stabilized particles isolated. This project intends to show that the particle solution can be sent directly from the mixer into a spray dryer without intermediate dilution or filtration operations. The time scale of exiting the mixing chamber to drying the solvent occurs fast enough to avoid particle degradation, therefore lowering operating cost and processing time. Keywords: [no keywords provided]

Source:

Purdue University / 2024

Topics:

No topics listed

Co-authors:

Katy Brauer