Authors:

Nicholas Herschel Burris

Date Created:

Not specified

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About Paper:

Open-Ephys is an open source GUI based electrophysiological experimental workstation software that is becoming a new standard for multi-channel neural engineering research. It is written using JUCE, a platform originally created for multi-track music performance and recording digital audio workstation (DAW), and instantiates a DAW for neuroscientists with a plug-in based architecture that recognizes neuroscientists may not be exceptional software developers. In this work, a custom plug-in was written to support experiments using mutli-channel Low Frequency Alternating Current (LFAC) stimulation. The LFAC waveform, a sinusoid between 0.1 and 10Hz, needed to be generated and presented to an implanted nerve electrode through a custom-built isolated voltage/current source. Although this is currently done using a function generator, expanding the study to multiple channels needed the NI USB-6251 device to implement 2 channels of 2MS/s stimulation and multi-channel 40kS/s recording simultaneously. The custom plug-in allows for control over LFAC frequency, phase, pulse-width time-high, pulse-width time-low, pulse phase, number of pulses in the train, number of LFAC periods before pulse-train, and device auto-connection across 2-channels of LFAC. With the current hardware, the LFAC is limited to a 10kHz maximum frequency and pulse widths of at least 0.5µs. These are both, well within the requirements of the application. The plug-in is currently undergoing usability testing ensuring that the GUI is functional. The plug-in paired with the NI device will then be used in-vivo benchtop application in an earthworm experiment to validate LFAC elicited nerve conduction blocks (NCB). Keywords: Neuromodulation; LFAC; Neuroscience; Low Frequency Alternating Current Block

Source:

Purdue University / 2025

Topics:

No topics listed

Co-authors:

Nicholas Herschel Burris