Authors:

McKinley Kathryn Underhill

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About Paper:

Sepsis remains one of the leading causes of mortality in horses and presents significant diagnostic challenges, particularly in its early stages. MicroRNAs (miRNAs), small, non-coding RNA molecules that regulate gene expression, offer a promising avenue for early detection of sepsis before clinical signs become evident. However, limited research exists on the role of miRNAs in equine sepsis. Our preliminary analysis identified several miRNAs that were significantly upregulated or downregulated in response to the LPS challenge. Blood plasma samples were collected from horses before and after LPS administration, and digital PCR was used to quantify changes in specific miRNA expression. The aim is to identify miRNAs that are differentially expressed in horses during experimentally induced sepsis via lipopolysaccharide (LPS) infusion. These findings suggest that certain miRNAs may serve as potential biomarkers for the early detection of sepsis in horses. Further research is needed to validate these candidates in clinical cases. Ultimately, understanding miRNA dynamics in sepsis could contribute to faster and more accurate diagnostics, as well as improved outcomes, for equine patients. Keywords: [no keywords provided]

Source:

Purdue University / 2025

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Co-authors:

McKinley Kathryn Underhill