Authors:

Maksymilian Mroczkowski

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About Paper:

Intraductal Papillary Mucinous Neoplasm (IPMN) is a cystic precursor lesion of pancreatic ductal adenocarcinoma characterized by mucin- producing papillary formations within pancreatic ducts. IPMNs are classified as main-duct, branch-duct, or mixed-type with varying malignant potential, progressing from low-grade dysplasia to invasive carcinoma. IPMN can lead to morphological changes in the pancreas, including main duct dilation, distal atrophy, multiple cystic lesions, and contour irregularities. We hypothesize that three-dimensional morphometric differences in the pancreas are predictive of malignancy risk in IPMNs. This retrospective study includes 180 patients with IPMN who underwent surgical resection at IU Health, along with 40 healthy individuals from the publicly available CHAOS dataset to provide normative baselines. The pancreas region of interest (ROI) was segmented, and local and global morphological features were extracted. These included volume-based metrics such as total volume, surface area, convexity, compactness, and sphericity. Additional features were derived from curvature analysis, fractal dimension, 3D moments, and spatial distribution within the ROI. Following feature extraction, univariate and multivariate analyses were performed to identify morphological biomarkers differentiating healthy tissue, low-grade IPMN, and high-grade IPMN. Quantitative features from the pancreatic ROI may show significant associations with malignancy risk in IPMN. Specific morphological parameters may serve as independent predictors of high-risk versus low-risk IPMN classification following multivariate analysis. This study establishes a quantitative relationship between pancreatic morphology and malignant transformation risk in patients with IPMN. By identifying morphological features that independently predict high-risk lesions, our findings may support non-invasive risk stratification and inform clinical decision- making in IPMN management. † Presenting Undergrad Author; ‡ Contributing Undergrad Author; * Undergrad Acknowledgment Keywords: IPMN; Morphometric Analysis; Pancreas; Intraductal Papillary Mucinous Neoplasm; Malignancy Risk

Source:

Purdue University / 2025

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Co-authors:

Maksymilian Mroczkowski